While every U.S. presidential election is unique, the upcoming one on November 5, 2024, is unprecedented, to say the least. In addition to being convicted on 34 felony counts, the Republican nominee and former President Donald J. Trump survived an assassination attempt. Moreover, the incumbent President Joe Biden, following mounting pressure from Democratic Party members and fundraisers, has withdrawn himself from the race, making way for a younger candidate. Although most Democratic Party heavyweights, including Biden, have endorsed Vice President Kamala Harris, she technically remains a presumptive nominee until the Democratic National Convention (DNC) scheduled for late August. The U.S. presidential election, like national elections in most democracies, will be mostly fought and won on domestic issues that directly affect the day-to-day lives of the American people. This report delves into some of the most contentious and consequential issues in America’s domestic politics. It covers topics such as the management of the economy, mounting concerns about unchecked immigration, the raging battle over abortion rights, and the influence of AI and deepfakes on this campaign season. The report attempts to identify why these issues will be prominent in this election and where the presumptive candidate of the Democratic Party and the Republican Party’s nominee stand on them.